biocellpharma

 The wfi distribution system  is the core unit of the whole pharmaceutical water system, and its main function is to ensure that the pressure, flow and temperature delivered to the process pipeline meet the process production requirements. The system uses online monitoring instruments such as flow, pressure, temperature, conductivity and TOC to conduct safety performance, real-time monitoring and trend analysis of water quality, and effectively control the load of microorganisms in water through periodic disinfection or sterilization. In addition, sampling valves shall be installed on the water supply starting point, water pipeline and end pipeline of the entire distribution system for water quality sampling. The whole system is mainly composed of inverter, exchanger, sampling valve, diaphragm valve, sanitary pipe fittings, online monitoring instrument and other supporting control systems. General Principles of Pharmaceutical Water Storage & Distribution Systems The stora...

 The wfi heat exchanger  (sterile double tube plate heat exchanger) is designed to work under the working conditions with the highest sanitary requirements, and the double tube plate structure design is adopted. The port of the sanitary shell and tube heat exchanger  adopts quick installation or flange structure, which effectively avoids the retention of liquid medicine at the connection between the heat exchanger and the pipeline, realizes the real full emptying design, and also makes the equipment disassembly convenient. The unique design of double tube sheet makes it easy to completely empty and keep the wfi heat exchange tube clean, which can ensure the complete separation of the shell side and tube side media, without internal welding points, and effectively eliminate the cross contamination between products and wfi heat exchange media. It is not polluted and can detect leakage, thus avoiding the risk of cross contamination of conventional sanitary heat exchanger. Te...

 The combination of reverse osmosis and EDI has overcome the deficiency that reverse osmosis effluent cannot be deeply desalted, and further removed trace carbon dioxide, residual salt, silicon dioxide, boron and total organic carbon plasma in RO water, greatly improving the quality of purified water. It is widely used in biotechnology, pharmacy and other industries that must generally comply with USP, EP，JP and ChP regulations. Specification of RO EDI Plant How Does edi in ro plant  Works？ The reverse osmosis device with EDI (reverse osmosis electrodeionization) is the most preferred purified water preparation technology in the pharmaceutical, food and biotechnology industries. It is basically a combination of reverse osmosis and electrodeionization processes. In reverse osmosis EDI system, single-stage or two-stage reverse osmosis is used to pre desalinate EDI feed water, and then deeply electrodeionize RO production water through EDI to finally produce high-purity water re...

 Separate the pure water from the solution containing solute with a semi permeable membrane that can only pass through water. At this time, the water on the pure water side will spontaneously pass through the semi permeable membrane and enter the solution side. The water surface on the solution side will rise. This phenomenon is penetration. When the liquid level rises to a certain height, the pressure on both sides of the membrane reaches equilibrium, and the liquid level on the solution side no longer rises. At this time, there is a pressure difference on both sides of the membrane, which is called osmotic pressure. If a pressure greater than the osmotic pressure is applied to the solution side, the water molecules in the solution will be squeezed to the pure water side. This process is just the opposite of osmosis, which is called reverse osmosis (RO). We can see from the process of reverse osmosis that due to the pressure, the water molecules in the solution enter the pure wate...

 The purified water distribution system is usually composed of purified water storage tank, circulating pump, ultraviolet sterilizer, one or more circulating pipes and water using points. The disinfection method is pasteurization or ozone disinfection, so double tube plate heat exchanger or ozone generator is required. The volume of the purified water storage tank shall meet the peak flow of purified water and have a certain balance relationship with the water yield of the purified water preparation system. The flow of circulating pump shall be greater than the sum of peak flow and return flow. Online relevant instruments detect the water quality, and alarm can be given once the water quality exceeds the standard. Unqualified water shall be directly discharged or recycled back to the previous tank. Design Features of PW Tank/ purified water skid ◆The design and manufacturing strictly comply with Chinese GMP, cGMP and FDA requirements. ◆Full drainage design ensures that the entire...